Paraffin injections
Shortly after the syringe was invented, paraffin became the first injectable filling agent. It was abandoned after migration, embolization and granulomas were described.[1]
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History
From paraffin in the late 1800s to the first FDA-approved collagen in 1981 and hyaluronic acid since 2003: the steps that made the treatment.
Timeline
Shortly after the syringe was invented, paraffin became the first injectable filling agent. It was abandoned after migration, embolization and granulomas were described.[1]
Knapp, Kaplan and Daniels treated 28 patients with human or bovine collagen injections and followed them for 3 to 18 months.[1]
Zyderm Collagen Implant, made from bovine collagen, was approved on July 22, 1981. Bovine collagen was the first agent FDA approved for cosmetic injection.[1][2]
Lemperle reported Artecoll, PMMA microspheres in collagen, from more than 600 patients and a prospective study of 118 patients, with results holding for 5 years.[1]
Duranti and colleagues treated 158 patients with Restylane. At 8 months, physicians rated 78.5% moderately or markedly improved.[1]
FDA approved Restylane on December 12, 2003. Its randomized trial against bovine collagen enrolled 138 patients.[1][2]
Sculptra was approved on August 3, 2004 for facial fat loss in people with HIV.[1]
Juvederm was approved on June 2, ArteFill on October 27 and Radiesse on December 22, 2006.[1][2][3]
Sculptra Aesthetic was approved on July 28, 2009. Restylane was approved for lip augmentation on October 11, 2011, and Belotero Balance on November 14, 2011.[1][2][3]
Juvederm Voluma XC was approved on October 22, 2013 for cheek augmentation by deep injection.[1]
Beleznay and colleagues collected 98 cases of vision changes from filler in the world literature. Radiesse was approved for the back of the hands on June 4, 2015.[1][2]
RHA 2, RHA 3 and RHA 4 were approved on October 19, 2017 for dynamic facial wrinkles.[1]
On October 8, 2021, FDA warned against needle-free devices such as hyaluron pens for lip and facial fillers, citing serious injuries and permanent harm.[1]
Juvederm Volux XC was approved for the jawline on July 29, 2022. Restylane Eyelight was approved for under-eye hollows on May 8, 2023, and Voluma XC for temples on October 6, 2023.[1][2][3]
People
Their published work led to the products and safety practices in use today.
First author of the 1977 report of injectable collagen in 28 patients.[1]
Co-author of the 1977 injectable collagen report.[1]
Published clinical results of PMMA microsphere filler (Artecoll) from more than 600 patients.[1]
Published a clinical and histological study of Restylane in 158 patients.[1]
First author of the randomized trial of Restylane against Zyplast collagen in 138 patients.[1]
First author of the 5-year follow-up of PMMA filler in nasolabial folds in 119 subjects.[1]
First author of the 3-year follow-up of Radiesse in nasolabial folds in 102 patients.[1]
First or senior author of the world-literature reviews of blindness from filler: 98 cases in 2015, 48 in 2019 and 365 in 2024.[1][2][3]
Co-author of the three world-literature reviews of blindness from filler.[1][2][3]
First author of the study of 1.7 million syringes comparing vascular occlusion with needles and cannulas.[1]
First author of a history of injectable facial fillers from paraffin to FDA-approved products.[1]